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Saved Stories – None: 7:40 AM 7/31/2020 – Cross-reactivity: Covid-19 and common cold Coronaviruses

Post author By mikenova12@gmail.com
Post date July 31, 2020

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Michael Novakhov (Mike Nova)

July 31, 2020

7:40 AM 7/31/2020

Could prior exposure to common cold viruses affect the severity of ...

Could prior exposure to common cold viruses affect the severity of ...

Cross-reactivity: Covid-19 and common cold Coronaviruses

“So how could their immune system have reactive T cells if they never had Covid-19? They were “probably acquired in previous infections with endemic” coronaviruses, the researchers — from various institutions in Germany and the United Kingdom — wrote in the new study. Using this T cell memory from another-yet-similar infection to respond to a new infection is called “cross-reactivity.”
…

“Alessandro Sette and Shane Crotty, both of the University of California, San Diego, wrote in a comment paper published in the journal Nature earlier this month, that “20–50% of unexposed donors display significant reactivity to SARS-CoV-2 antigen peptide pools,” based on separate research — but they noted that the source and clinical relevance of the reactivity remains unknown.

Sette and Crotty wrote that “it is now established that SARS-CoV-2 pre-existing immune reactivity exists to some degree in the general population. It is hypothesized, but not yet proven, that this might be due to immunity to” common cold coronaviruses.”

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SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 – Google Search https://www.google.com/search?q=SARS-CoV-2-reactive+T+cells+in+healthy+donors+and+patients+with+COVID-19&newwindow=1&rlz=1C1CHBF_enUS733US733&sxsrf=ALeKk031yCv3gi12U4_-nt_gGC32vdG47g%3A1596195227485&source=lnms&tbm=nws&sa=X&ved=2ahUKEwjHz5rMsvfqAhXGMd8KHQHHBW8Q_AUoAnoECBYQBA&biw=1536&bih=722&dpr=1.25 …

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Michael Novakhov@mikenov

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 – Google Search https://www.google.com/search?q=SARS-CoV-2-reactive+T+cells+in+healthy+donors+and+patients+with+COVID-19&rlz=1C1CHBF_enUS733US733&oq=SARS-CoV-2-reactive+T+cells+in+healthy+donors+and+patients+with+COVID-19&aqs=chrome..69i57j69i60l2.2749j0j7&sourceid=chrome&ie=UTF-8 …

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Michael Novakhov@mikenov

Cross-reactivity: Covid-19 and common cold Coronaviruses – Google Search https://www.google.com/search?q=Cross-reactivity%3A+Covid-19+and+common+cold+Coronaviruses&rlz=1C1CHBF_enUS733US733&oq=Cross-reactivity%3A+Covid-19+and+common+cold+Coronaviruses&aqs=chrome..69i57j69i58.34645j1j7&sourceid=chrome&ie=UTF-8 …

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Michael Novakhov@mikenov

We detected SARS-CoV-2 S-reactive CD4+ T cells in 83% of patients with COVID-19 but also in 35% of HD. S-reactive CD4+ T cells in HD reacted primarily to C-terminal S epitopes, which show a higher homology to spike glycoproteins… https://www.nature.com/articles/s41586-020-2598-9 …

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

nature.com

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Michael Novakhov@mikenov

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 | Nature https://www.nature.com/articles/s41586-020-2598-9 …

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

nature.com

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Michael Novakhov@mikenov

Coronavirus news and live updates from around the world https://www.cnn.com/world/live-news/coronavirus-pandemic-07-31-20-intl/index.html …

Coronavirus news and live updates from around the world

The coronavirus pandemic has brought countries to a standstill. In many places, as countries reopen, Covid-19 cases are on the rise. Follow here for the latest.

cnn.com

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