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Disease X-19 Medical Review

medrxiv Subject Collection: Infectious Diseases: Kinetics of SARS-CoV-2 Antibody Avidity Maturation and Association with Disease Severity

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The kinetics of immunoglobulin G (IgG) avidity maturation during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was studied. The IgG avidity assay used a novel label-free immunoassay technology to test IgG against the virus spike protein receptor-binding domain (RBD). The technology, thin-film interferometry (TFI), is able to sense the formation of immune complex on a sensing probe without attaching a reporter (enzyme, fluorophore, etc.). It was found that there was a strong correlation between IgG antibody avidity and days since symptom onset (p
medrxiv Subject Collection: Infectious Diseases

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