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Disease X-19 Medical Review

medrxiv Subject Collection: Infectious Diseases: Candida (Diutina) mesorugosa in Non-Albicans Candida Species Clinical Isolates in Southwest Nigeria

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Introduction The emerging role of non-albicans Candida species (NACS) as causal agents of mild to life-threatening mycoses is increasingly being appreciated. Some NACS are known for intrinsic resistance or reduced susceptibility to some antifungal drugs. To inform therapeutic options and management of candidiasis, we embarked on Candida species surveillance in Southwest Nigeria. Method We obtained retrospective yeast isolates from urogenital samples of patients in a tertiary hospital in south western Nigeria. Among 47 isolates identified phenotypically, we encountered a yeast which failed to produce pseudohyphae in human serum but was morphologically similar to Candida albicans. We characterized this yeast by sequencing the internal transcribed spacer (ITS1-5.8S-ITS2) region of the ribosomal DNA. Results A BLAST search and sequence homology identified the yeast as Candida (Diutina) mesorugosa, with a strong bootstrap. Conclusion Candida mesorugosa, a rarely isolated yeast from clinical samples worldwide, should be considered among potentially relevant NACS in Nigerian clinics. To the best our knowledge, this is the first report of Candida mesorugosa from a patient sample in Nigeria. This finding confirms the need for more specific methods, such as DNA sequencing, for extensive surveillance of NACS. Key words: Candida mesorugosa, Candida rugosa complex, Non-albicans Candida species surveillance, ribosomal DNA sequencing, NACS

medrxiv Subject Collection: Infectious Diseases


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